Inofolic for PCOS Patients

5 inofolic1

What is PCOS?

About 10% of women have Polycystic Ovary Syndrome (PCOS) and a further 10% have polycystic or multi-cystic ovaries on ultra sound scan. PCOS is a significant problem in fertility and long term health as it puts women at a five-fold increase of developing type 2 diabetes.

PCOS is usually diagnosed by:

  • irregular periods
  • anovulation (failure to release an egg)
  • polycystic ovaries on scan
  • raised testosterone levels

However, a woman with PCOS may not have all these problems.  In fact PCOS patients are not all the same!

They frequently struggle to maintain a healthy weight (BMI 20 to 25), notice they are troubled by ‘teenage’ acne and may have excessive facial and body hair.

65 to 80% of women diagnosed with PCOS will have increased insulin resistance and new research suggests that this feature is responsible for many of the features associated with PCOS, including infertility and an increased risk of miscarriage.

What is Insulin resistance?

Insulin resistance is a physiological condition in which the cells of the body fail to respond to the normal action of insulin which is to help absorb excess glucose from the blood and store it as fat or glycogen.

In PCOS there is a fault in this process which results in glucose levels staying high, which makes the pancreas secrete more insulin – and a ‘vicious cycle’ develops which causes androgen levels to increase. This cycle can be reversed by taking supplements of myo-inositol to correct this fault.

The ‘vicious cycle’ of increased insulin resistance
The ‘vicious cycle’ of increased insulin resistance

Inofolic as a dietary supplement for women with PCOS

Inofolic contains myo-inositol and folic acid.

Myo-inositol is a ‘natural’ carbohydrate and is one of nine stereoisomers of inositol, cyclohexane-1,2,3,4,5,6-hexol. It has the same formula as glucose
Myo-inositol is a ‘natural’ carbohydrate and is one of nine stereoisomers of inositol, cyclohexane -1,2,3,4,5,6-hexol. It has the same formula as glucose

A dose of two sachets a day provides adequate levels of myo-inositol and the recommended pre-pregnancy dose of folic acid (400 micrograms).

The benefits of Inofolic supplementation for women with PCOS

Clinical trials have shown that Inofolic supplementation increases insulin sensitivity by 84% and helps with weight loss. It produces ovulation in the majority of women with anovulation due to PCOS and helps ovulation in women who fail to respond to ovulation induction (OI).

Taken during IVF treatment it has been shown to improve egg and embryo quality and reduce the risk of OHSS. It can be taken throughout pregnancy and reduces the incidence of gestational diabetes (GDM).

There are many pharmacological preparations used alongside IVF medications to help with insulin sensitivity (eg Metformin). Unlike these medications, Inofolic is of vegetable origin (with no gluten or lactose) and has no unpleasant side effects such as abdominal cramps, bloatedness and diarrhoea.

How is Inofolic taken?

Ideally patients with PCOS should start taking Inofolic at least a month before starting fertility treatment, and continue with it during their treatment cycle and throughout pregnancy.

Patients with PCOS who are struggling with weight loss while preparing for fertility treatment should take Inofolic for three months in conjunction with an ultra-low carbohydrate diet, high in lean protein and leafy vegetables (see Midland Fertility infosheet Diet Plan for PCOS). Inofolic should only be dissolved in still or sparkling water, NOT fruit juice, squash, or alcohol etc.

What is included in the cost?

The cost of Inofolic treatment is in addition to other medications and investigations or treatments, or all other services at Midland Fertility.

What is not included in the cost?

The cost of Inofolic does not include any other fertility investigations, treatments, preservation services, or medications for either partner.

Success rates

Please refer to the Success Rates section for details of the most recent published results for all treatments.


Cost of Inofolic (per treatment) at Midland Fertility: £20.00

Please refer to the current List of Charges for the costs of all services at Midland Fertility.

Further information

Alternatively go to Download Literature, and download the following infosheets:

  • Diet Plan for PCOS
  • Inofolic for PCOS Patients

LU: 15/6/16/JAA